摘要 |
<p>Substituted biphenyl and phenyl pyridyl derivatives of formula (I), their isomers and their salts are new. R1 = 3-7C cycloalkyl, phenyl, naphthyl, optionally unsaturated mono- or bicyclic heterocycle having 1-3 O, S or N, 1-6C alkyl or 1-6C alkenyl (sic) (all optionally substituted); A = a bond (provided that R1 is other than C1 or C2 alkyl) or O, S, -CO-, -C(=N-ORc)- or -CH(ORc)-; Rc = H, 1-6C alkyl or 3-7C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkenyl (sic), 1-6C alkynyl (sic) or 3-7C cycloalkyl (all optionally substituted) halo, formyl, carboxy, 1-6C alkylcarbonyl, 3-7C cycloalkylcarbonyl, 1-6C alkoxycarbonyl, 3-7C cycloalkoxycarbonyl, carbamoyl (optionally substituted), amino (optionally substituted by one or two 1-6C alkyl, 1-6C acyl, 3-7C cycloalkyl or forming with the N atom which bears them a 5-7 membered heterocycle containing 1-3 O, N or S (sic)), formamido, CN, amidino (optionally substituted), hydroxyaminomethyl (optionally substituted), amide-oxime (optionally substituted), hydrazono (optionally substituted), -C(R21)=N-O-R22 or -C(R21)=N(O)-R23; R21 = H, 1-6C alkyl or 3-7C cycloalkyl; R22 = H, 1-6C alkyl, 3-7C cycloalkyl or 1-6C acyl; R23 = 1-6C alkyl or 3-7C cycloalkyl; R3 = H, 1-6C alkyl, 3-7C cycloalkyl or 1-6C acyl or =C(R2)-C(X-R3)= forms an unsaturated 5-membered heterocyclic ring of formula (i); X = O, S or NR"; R" = H, 1-6C alkyl, 3-7C cycloalkyl or 1-6C acyl; ring B is phenyl or pyridyl; Ra, Rb = H, halo, 1-6C alkyl, OH, 1-6C alkoxy, carboxy, 1-6C polyhaloalkyl, CN, NO2, 1-6C alkoxycarbonyl, 3-7C cycloalkoxy carbonyl, amino (optionally substituted), carbamoyl (optionally substituted); provided that when A is a bond or O, B is phenyl, R1 is 3-7C cycloalkyl, phenyl or naphthyl (all optionally substituted), X is O, NH or amino(1-6C alkyl) and R3 is H or 1-6C alkyl, then R2 is not carboxy.</p> |