发明名称 |
TREATMENT OF PARTIAL GROWTH HORMONE INSENSITIVITY SYNDROME |
摘要 |
<p>Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering a dose of greater than 0.3 mg/kg/week of growth hormone, preferably growth hormone with a native human sequence, with or without an N-terminal methionine, to the patient. The patient is characterized as having a height of less than about -2 standard deviations below normal for age and sex, serum levels of high-affinity growth hormone binding protein and IGF-I that are at least 2 standard deviations below normal levels, and a serum level of growth hormone that is at least normal. In another such method, the same patient population is treated with an effective amount of IGF-I alone or in combination with an amount of growth hormone that is effective in combination with IGF-I.</p> |
申请公布号 |
GR3036901(T3) |
申请公布日期 |
2002.01.31 |
申请号 |
GR20010401771T |
申请日期 |
2001.10.16 |
申请人 |
GENENTECH, INC. |
发明人 |
ATTIE, KENNETH;CARLSSON, LENA, M., S.;GESUNDHEIT, NEIL;GODDARD, AUDREY |
分类号 |
C12N15/09;A61K38/00;A61K38/27;A61K38/30;A61P3/00;A61P5/00;A61P43/00;C07K14/61;C07K14/65;C07K14/72;(IPC1-7):A61K38/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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