Sphärische, magnetische Silica-Partikel mit einstellbarer Teilchen- und Porengröße sowie einstellbarem Magnetgehalt für die Aufreinigung von Nukleinsäuren und anderen Biomolekülen

摘要

The invention relates to a method for producing magnetic SiO2 particles, comprising the following steps: a) alkoxysilanes are dispersed in water, acid-catalytically hydrolyzed and condensed to form an SiO2 hydrosol; b) a magnetic particle-sol mixture is produced by adding magnetic particles, for example usual magnetic particles, magnetic colloids and/or ferrofluids to the SiO2 hydrosol; c) dispersing the magnetic particle-sol mixture in an organic solvent which is immiscible with water; and d) adding a base to the magnetic particle-sol mixture during or after the dispersion in the organic solvent in order to form a gel.