发明名称 |
ALPHA-ACYL AND ALPHA-HETEROATOM-SUBSTITUTED BENZENALPHA-ACYL AND ALPHA-HETEROATOM-SUBSTITUTED BENZENE ACETAMIDE GLUCOKINASE ACTIVATORS E ACETAMIDE GLUCOKINASE ACTIVATORS |
摘要 |
Compounds fo the formula (I) wherein R1 and R2 are independently hydrogen or substituents; R3 is lower alkyl having from 2 to 4 carbon atoms or a 5 to 7- membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having one heteroatom selected from oxygen and sulfur; R4 is -C(O)NHR5, or is R6; R 6 is a heteroaromatic ring connected by a ring carbon atom to the amide group and having nitrogen adjacent to the connecting ring carbon atom; and X is oxygen, sulfur, sulfonyl of carbonyl; are glucokinase acitvators useful for treating type II diabetes. |
申请公布号 |
CA2416229(A1) |
申请公布日期 |
2002.01.31 |
申请号 |
CA20012416229 |
申请日期 |
2001.07.11 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
KESTER, ROBERT FRANCIS;SARABU, RAMAKANTH |
分类号 |
C07D277/20;A61K31/17;A61K31/351;A61K31/426;A61K31/427;A61K31/4402;A61P3/10;A61P43/00;C07C273/18;C07C275/50;C07C315/04;C07C317/46;C07D213/75;C07D277/18;C07D277/44;C07D277/46;C07D309/12;C07D417/12;(IPC1-7):C07D277/46;A61K31/44 |
主分类号 |
C07D277/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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