METHOD AND APPARATUS FOR REDUCING ELECTROPORATION-MEDIATED MUSCLE REACTION AND PAIN RESPONSE

摘要

This invention is a method for delivery of an agent to a cell using electroporation (15) including positioning first, and second electrodes (16) such that an electrical signal passed therebetween passes through the cell. The method also includes passing an electrical signal of a frequency greater than about 10 kHz between the electrodes. In one embodiment the signal is a bipolar waveform. In another, the electrodes are positioned at a treatment site (30), e.g., a tumor (34), for in vivo delivery of an agent.