发明名称 |
LIQUID OPHTHALMIC SUSTAINED RELEASE DELIVERY SYSTEM |
摘要 |
<p>Disclosed is a sustained release liquid aqueous ophthalmic delivery system and a method of providing a slow and sustained release of ophthalmic treating agents to the eye of a mammal which comprises administering to the eye of a said mammal an effective amount of a homogeneous liquid aqueous ophthalmic pharmaceutical composition, of pH between about 3.0 and about 6.2, which is adminstrable in drop form and which comprises an ophthalmically effective concentration of a said ophthalmic treating agent and about 0.05% to about 10% by weight of the polymer chitosan; said polymer consisting essentially of (A) monomeric beta (1->4)-D-glucosamine linked units and of (B) monomeric beta (1->4)-D-glucosamine linked units which are scattered randomly in the molecule of the polymer, the numerical proportions of A and B being from about 60 to about 99% of A and about 1 to about 40% of B, the viscosity rating being from about 3 to about 3000 cps; in which method, upon contact with the higher pH of the ocular fluid, said liquid formulation is converted to a stiff gel from which the ophthalmic treating agent is slowly released over a prolonged period of time.</p> |
申请公布号 |
GR3036884(T3) |
申请公布日期 |
2002.01.31 |
申请号 |
GR20010401754T |
申请日期 |
2001.10.16 |
申请人 |
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. |
发明人 |
YEN, SHAU-FONG;REED, KENNETH W. |
分类号 |
A61K9/08;A61K9/00;A61K47/36;(IPC1-7):A61K9/08 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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