发明名称 |
VETO CELLS EFFECTIVE IN PREVENTING GRAFT REJECTION AND DEVOID OF GRAFT VERSUS HOST POTENTIAL |
摘要 |
A method of transplanting a transplant derived from a donor into a recipient is disclosed. The method comprises the steps of (a) transplanting the transplant into the recipient; and (b) administering to the recipient a dose including non-alloreactive anti-third party cytotoxic T-lymphocytes (CTLs), wherein the non-alloreactive anti-third party CTLs are generated by directing T-lymphocytes of the donor against a third party antigen or antigens, the dose is substantially depleted of T-lymphocytes capable of developing into alloreactive CTLs, thereby preventing or ameliorating both graft rejection by the recipient and graft versus host disease.
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申请公布号 |
WO0149243(A3) |
申请公布日期 |
2002.01.31 |
申请号 |
WO2000IL00872 |
申请日期 |
2000.12.28 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;REISNER, YAIR;MARTELLI, MASSIMO |
发明人 |
REISNER, YAIR;MARTELLI, MASSIMO |
分类号 |
A61K35/12;A61K35/28;A61K39/00;C12N5/02;C12N5/0783;(IPC1-7):C12N15/85;A61K35/00;A61K38/00 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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