发明名称 |
PROTEIN |
摘要 |
The present invention provides proteins and peptides derived from <i>Streptococcus pneumoniae</i>, type 3, which bind the complement factor H (fH). These proteins and peptides show a homology of at least 50 %, preferably at least 60 %, and most preferably at least 70 % with the subsequence from Thr38 to Lys 149 of the sequence disclosed herein as SEQ ID NO:1. The above subsequence, which is located in the amino-terminal of a surface protein isolated from <i>Streptococcus Pneumoniae</i>, type 3, is highly associated with binding of fH. In another aspect, the invention relates to proteins and peptides showing a homology of at least 85 %, preferably at least 95 %, and most preferably at least 99 % with the Hic protein, the amino acid sequence of which is disclosed is SEQ ID NO:1. The invention also provides vaccine compositions comprising the above proteins and peptides. |
申请公布号 |
WO0208426(A2) |
申请公布日期 |
2002.01.31 |
申请号 |
WO2001EP08409 |
申请日期 |
2001.07.19 |
申请人 |
HANSA MEDICAL AB;BJORCK, LARS;SJOHOLM, ANDERS;JANULCZYK, ROBERT;POZZI, GIANNI;IANNELLI, FRANCESCO |
发明人 |
BJORCK, LARS;SJOHOLM, ANDERS;JANULCZYK, ROBERT;POZZI, GIANNI;IANNELLI, FRANCESCO |
分类号 |
A61K39/00;A61K47/48;C07K14/315;C12N1/21;C12N15/31 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|