MOLECULAR SWITCHES II

摘要

A method of selecting one or more components of a switching system, the switching system comprising: (i) a first molecule and (ii) a second molecule, in which the first molecule binds to the second molecule in a manner modulatable by a ligand, and (iii) a ligand, the method comprising the steps of: (a) determining the degree of binding between a candidate first molecule and a candidate second molecule in the presence of a candidate ligand; (b) determining the degree of binding between the candidate first molecule and the candidate second molecule in the absence of the candidate ligand; and (c) identifying a first molecule / second molecule pair in which the binding of the first molecule to the second molecule differs in the presence and absence of a ligand; and (d) optionally isolating and/or identifying first molecule, the second molecule or the ligand.