IMPLANTABLE BIOCOMPATIBLE ANIMAL TISSUE

摘要

Undesired agents reducing biocompatibility are selectively and substantially completely removed from tissue of animal origin intended for implantation in medical devices. Ambient pressure and temperature of a supercritical fluid solvent comprising carbon dioxide are adjusted to selectively remove one or more undesired agents from animal tissue perfused by the solvent. Calcification tendency of implantable tissue of animal origin is estimated as directly proportional to amounts of calcific agents removable from the tissue. Tissue engineering matrices are prepared from tissues of animal origin by selective and substantially complete removal of undesired agents incorporated in the tissue.