发明名称 ISOXAZOLINE DERIVATIVES AS FIBRINOGEN RECEPTOR ANTAGONISTS
摘要 The invention relates to isoxazoline derivatives which are presented as ester or salt of N3[2-(3-(4-formamidinophenyl)-isoxazoline -5(R)-yl)-acetyl]-N2(n-butyloxycarbonyl)-2,3-(S)-diaminopropionate prodrug, said ester being selected from methyl, ethyl or isopropyl, and said salt being selected from acetate, hydrochloride, benzenesulphonate, methanesulphonate or p-toluenesulphonate, useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen, in pharmaceutical compositions containing such compounds, single or in combination with other therapeutical agents for inhibiting the platelet aggregation, as thrombolytic agents and/or for treating thromboembolic disorders.
申请公布号 RO117324(B) 申请公布日期 2002.01.30
申请号 RO19970002195 申请日期 1996.05.30
申请人 THE DU PONT MERCK PHARMACEUTICAL COMPANY, WILMINGTON, DELAWARE 发明人 WITYAK JOHN;CAIN GARY AVONN;BATT DOUGLAS GUY;PINTO DONALD;HUSSAIN MUNIR ALWAN;XUE CHU BIAO;SIELECKI-DZURDZ THAIS MOTRIA;OLSON RICHARD ERIC;DEGRADO WILLIAM FRANK;MOUSA SHAKER AHMED
分类号 A61K31/42;A61K31/423;A61K31/425;A61K31/435;A61K31/44;A61K31/445;A61K31/47;A61K31/495;A61K31/496;A61K31/50;A61K31/505;A61K31/535;A61K31/5377;A61K31/55;A61K31/66;A61K31/665;A61K45/00;A61P1/00;A61P3/08;A61P3/10;A61P7/02;A61P7/04;A61P9/08;A61P9/10;A61P11/00;A61P17/00;A61P19/10;A61P27/02;A61P27/14;A61P29/00;A61P31/04;A61P35/00;A61P37/00;A61P37/08;A61P43/00;C07D261/04;C07D261/06;C07D261/10;C07D261/12;C07D261/18;C07D261/20;C07D413/04;C07D413/06;C07D413/12;C07D413/14;C07D417/12;C07D498/10;C07F7/10;C07F9/653;C07F9/6571;(IPC1-7):C07D261/04;C07D413/10 主分类号 A61K31/42
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