摘要 |
The invention relates to isoxazoline derivatives which are presented as ester or salt of N3[2-(3-(4-formamidinophenyl)-isoxazoline -5(R)-yl)-acetyl]-N2(n-butyloxycarbonyl)-2,3-(S)-diaminopropionate prodrug, said ester being selected from methyl, ethyl or isopropyl, and said salt being selected from acetate, hydrochloride, benzenesulphonate, methanesulphonate or p-toluenesulphonate, useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen, in pharmaceutical compositions containing such compounds, single or in combination with other therapeutical agents for inhibiting the platelet aggregation, as thrombolytic agents and/or for treating thromboembolic disorders.
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