Glucose-1-phosphate thymidylyltransferase and method for selecting inhibitors thereof

摘要

There is provided a method of obtaining selecting agents which inhibit the enzyme glucose-1-phosphate thymidylyltransferase (Rm1A) based upon analysis of a model of the active and regulatory site (s) of Rm1A and interaction therewith by a potential inhibitory agent. The invention is based upon the provision of information on the structure of Rm1A obtained through X-ray diffraction studies since a crystallised form of Rm1A was obtained for the first time. The purified and crystallised from of Rm1A, obtained from Psemdomononas aeruginosa is also described.