| 摘要 |
A production method for freeze-dried products for preventing the crumbling and scattering of freeze-dried cake and shortening time required for frozen water content to sublimate, the method comprising the steps of forming a frozen layer of an aqueous solution containing a material to be dried in a freeze-drying vessel covered on part or entire of the inner surface thereof with an ice layer, and freeze-drying the material to be dried, characterized in that the frozen layer is formed so that the ice layer is partially exposed to the surface of the frozen layer of the aqueous solution containing the material to be dried or a temperature control is effected so that the temperature of the freeze-drying vessel is kept at at least 0<C in the initial stage of sublimation of frozen water content and then is lowered to up to 0 DEG C during the sublimation. |
