Novel antisense oligonucleotide derivatives against wilms's tumor gene

摘要

Antisenses against WT1 which comprise oligonucleotide derivatives containing 1 or more sugar-modified nucleotide analog units represented by the following general formula (2) wherein B represents a pyrimidine nucleic acid base, a purine nucleic acid base or an analog thereof. These antisenses, which are antisenses against Wilms's tumor (WT1) gene, are expected as antisense oligonucleotide derivatives capable of binding to WT1 at a high affinity in cells to thereby efficiently regulate or inhibit the expression of this gene and being highly resistant to nucleases.