Water soluble microflake through air-gap and process therefore

摘要

Disclosed is a multi-layered, air-gap sheet of chitosan with a regular lamellar structure, which retains drug for a prolonged period of time and makes drug distributed uniformly therethroughout. In the lamellar structure chitosan thin films 1-50 mu m thick are layered at such regular gaps of 1-10,000 mu m in the direction perpendicular or horizontal to the surface of the sheet or slanting against the surface of the sheet that drugs can be homogeneously dispersed throughout the sheet. It is a novel form which can be effectively used as a clinical-pathological agent with high coatability onto skin, maximizing the medicinal efficacy of chitosan. The sheet of the present invention is highly suitable for use as a chitosan source for a broad spectrum of applications because it can be readily dissolved in water owing to its large surface area.