A Diesel fuel filter (1) with interchangeable cartridge, which comprises a filtering mass or cartridge (2) which is contained within a container which has a side wall (3) and a bottom (4) and is provided with a lid (6) which is fixed detachably. The filter further comprises a duct (8) which is located in a peripheral region of the container and is suitable to connect a fuel intake connector (9) to a duct (7) which is formed within the lid (6) and is provided with passages (10) which open onto the protion of space (11) between the filtering mass (2) and the side wall (3) of the container, so as to allow the fuel to access the filtering mass (2), through which it flows from the outside inward. A fuel discharge connector (14) is furthermore provided at the bottom (4) of the container and is open in the central region of the portion of space delimited inside the filtering mass (2).