| 发明名称 |
PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS |
| 摘要 |
The present invention relates to compounds of formula (I) wherein R<1>, R<2>, R<3>, R<4>, R<5> and X are as defined in the description and the claims and pharmaceutically acceptable esters and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
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| 申请公布号 |
WO0206224(A1) |
申请公布日期 |
2002.01.24 |
| 申请号 |
WO2001EP07995 |
申请日期 |
2001.07.11 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
AEBI, JOHANNES;DEHMLOW, HENRIETTA;KITAS, ERIC, ARGIRIOS |
| 分类号 |
A61K31/40;A61K31/401;A61K31/4025;A61K31/454;A61K31/455;A61K31/4709;A61K31/501;A61P3/10;A61P9/00;A61P9/04;A61P9/06;A61P9/10;A61P9/12;A61P11/06;A61P13/12;A61P15/00;A61P17/02;A61P25/00;A61P25/06;A61P27/02;A61P27/06;A61P31/04;A61P35/00;A61P37/06;C07D207/16;C07D207/263;C07D401/12;C07D403/06;C07D405/12;C07D409/12;(IPC1-7):C07D207/16 |
主分类号 |
A61K31/40 |
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