NOVEL HAPTOTACTIC PEPTIDES

摘要

Novel peptide sequences homologous to the known fibrinogen derived haptotactic peptides, C beta and C alpha E, are disclosed. The novel peptides are derived from proteins related or unrelated to fibrinogen including a peptide adjacent to fibrinogen gamma -chain C terminus denoted pre-C gamma as well as isotypes of angiopoietin, human microfibril-associated glycoprotein (mfap) and tenascins. Novel peptides having significant homology to the known fibrinogen derived haptotactic peptides are now shown to possess cell attraction activities. Active fragments comprising shorter 8-10 mer peptides are also disclosed, and shown to elicit significant haptotactic activity from a variety of cells, such as fibroblasts, endothelial and smooth muscle cells. The homologous peptides disclosed permit delineation of consensus sequences for haptotactic activity. The peptides are useful in pharmaceutical compositions alone or in conjunction with a medical device or implant.