发明名称 |
MATRIX METALLOPROTEINASE INHIBITORS |
摘要 |
A compound of the general formula (I) wherein Y is O or S; n is 1, 2, 3 or 4; X represents hydroxamic acid, carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group; R2 represents hydrogen, (C1-8)alkyl, (C2-6)alkenyl, (C3-8)cycloalkyl, aryl(C0-6)alkyl or heteroaryl(C0-6)alkyl; provided that if A, A', Z and R5 are all bonds, and s and t are both 0 (zero), then R6 is different from hydrogen; or a salt, hydrate or solvate thereof. The compounds are valuable for human and veterinary therapy. |
申请公布号 |
WO0206293(A1) |
申请公布日期 |
2002.01.24 |
申请号 |
WO2001DK00464 |
申请日期 |
2001.07.03 |
申请人 |
LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOEVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB);SOERENSEN, MORTEN, DAHL;BLAEHR, LARS, KRISTIAN, ALBERT;CHRISTENSEN, METTE, KNAK |
发明人 |
SOERENSEN, MORTEN, DAHL;BLAEHR, LARS, KRISTIAN, ALBERT;CHRISTENSEN, METTE, KNAK |
分类号 |
A61K31/664;A61K31/675;A61P1/02;A61P1/04;A61P17/06;A61P17/16;A61P19/02;A61P19/10;A61P25/00;A61P27/02;A61P27/06;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C07F9/6584;(IPC1-7):C07F9/658 |
主分类号 |
A61K31/664 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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