Surprinsingly, it has been discovered that the core protein antigen of Toscana virus can induce a protective humoral response. The invention relates to compositions comprising Toscana virus nucleoprotein. These may be used in the treatment or prophylaxis of Toscana virus infection. Also provided is the use of an internal virus antigen in the manufacture of a medicament for eliciting a neutralising humoral anti-viral immune response.
申请公布号
WO0144288(A3)
申请公布日期
2002.01.24
申请号
WO2000IB02031
申请日期
2000.12.18
申请人
UNIVERSITA'DEGLI STUDI DI SIENA;CUSI, MARIA, GRAZIA;VALASSINA, MARCELLO;VALENSIN, PIER, EGISTO