发明名称 |
T-CELL VACCINATION FOR THE TREATMENT OF MULTIPLE SCLEROSIS |
摘要 |
Disclosed are methods and compositions useful for the treatment of autoimmune diseases. Methods for producing vaccines against autoreactive T-cells are disclosed. The vaccines so produced are capable of restoring a degree of immunologic self-tolerance sufficient to slow or halt the progression of autoimmune disorders. In a preferred embodiment of the invention, a vaccine is derived from attenuated autologous autoreactive T-cells that recognize a variety of myelin-derived proteins. Such vaccine compositions are useful for immunologic therapy for the treatment of multiple sclerosis (MS).
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申请公布号 |
US2002009448(A1) |
申请公布日期 |
2002.01.24 |
申请号 |
US19980156509 |
申请日期 |
1998.09.17 |
申请人 |
WEINER LESLIE P.;CORREALE JORGE D. |
发明人 |
WEINER LESLIE P.;CORREALE JORGE D. |
分类号 |
A61K35/14;A61K39/00;A61P37/00;C12N5/08;(IPC1-7):A61K39/395;A61K39/38 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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