NOVEL IL-8 RECEPTOR ANTAGONISTS

摘要

The invention concerns novel compounds inhibiting the action of CXC chemokines such as IL-8, Gro, NAP-2, ENA-78 etc. on their receptors, the method for preparing them and their use for obtaining medicines. The invention is characterised in that it consists in novel indole derivatives selected among the set consisting of: i) products of formula (I) wherein: X represents a double bond -C=C- or a sulphur atom; R>1< represents a halogen, a nitro, a trifluoromethyl or a C>1<-C>3< alkyl group; R>2<, R>3< and R>4< represent each independently a hydrogen atom, a halogen, a C>1<-C>3< alkyl, a nitro, a trifluoromethyl or a cyano group, or R>2< and R>3< together form with the aromatic ring whereto they are bound, a condensed aromatic cycle; n is equal to 2 or 3, and ii) additive esters and salts with a mineral or organic base of formula (I).