发明名称 |
PHENYL-KETO-IMIDAZOLIDINE THIOAMIDE DERIVATIVES |
摘要 |
It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
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申请公布号 |
US2002010338(A1) |
申请公布日期 |
2002.01.24 |
申请号 |
US20010863567 |
申请日期 |
2001.05.23 |
申请人 |
HULL KENNETH G.;SIDDURI ACHYTHARAO;TILLEY JEFFERSON W. |
发明人 |
HULL KENNETH G.;SIDDURI ACHYTHARAO;TILLEY JEFFERSON W. |
分类号 |
A61K31/145;A61K31/167;A61K31/198;A61K31/223;A61K31/4166;A61K31/44;A61K31/4406;A61K31/4409;A61K31/505;A61P1/00;A61P11/06;A61P29/00;A61P43/00;C07C327/46;C07C327/48;C07D213/56;C07D213/82;C07D231/08;C07D233/38;C07D233/84;C07D239/26;C07D239/28;C07D401/06;(IPC1-7):C07D213/56;C0727/44 |
主分类号 |
A61K31/145 |
代理机构 |
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代理人 |
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