EXTERNAL GEL PREPARATION CONTAINING LOCAL ANESTHETICS

摘要

PURPOSE: An external gel preparation containing local anesthetics is provided, which preparation has an improved skin-penetrating activity. CONSTITUTION: The external gel preparation contains 0.5 to 12.0 wt.% of topical anaesthetics, 0.3 to 50 wt.% of gel material, 0.5 to 15 wt.% of skin penetration-improving agent and 1 to 15 wt.% of emulsifier, in which the topical anaesthetic is selected from lidocaine or its salt, benzocaine, and prolicaine or its salt; the gel material is selected from polyoxyethylene-polypropylene copolymer, carboxyvinyl copolymer and hydroxyethyl cellulose; the skin penetration-improving agent is diethyleneglycol monoethylether; and gel emulsifier is acrylate/C10-30 alkylacrylate copolymer.