3-AMIDINOBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES IN THE PRODUCTION THEREOF

摘要

The present invention relates to 3-amidinobenzenesulfonamide derivatives represented by the general formula: <CHEM> wherein R<1> represents a hydrogen atom or a hydroxy group; Y represents a single bond or an oxygen atom; and R<2> represents a lower alkyl group or a group represented by the general formula: <CHEM> (wherein n represents 1 or 2; and T represents a hydrogen atom, a lower acyl group, a halo (lower acyl) group or a group represented by the general formula: -C(=NH)-W (wherein W represents a lower alkyl group)), and pharmaceutically acceptable salts thereof, which have an excellent activated blood coagulation factor X inhibitory activity and are useful as activated blood coagulation factor X inhibitors, and to pharmaceutical compositions comprising the same and intermediates thereof.