| 摘要 |
PROBLEM TO BE SOLVED: To easily predict a new biological/functional activity unknown yet such as a decarboxylation activity of prion protein and aβ-amyloid protein precursor to oxaloacetate and a biological activity analogous to calcitonin and human growth hormone. SOLUTION: An EIIP index number is given to amino acid (or nucleic acid) in an amino acid sequence area existing in the complete amino acid sequence of an optional protein and containing a known motif related to an active site, and a frequency spectrum obtained by discrete Fourier transformation of an obtained number sequence (EIIP sequence) and a frequency obtained by discrete Fourier transformation of the EIIP sequence of the complete amino acid sequence are found. Subsequently, a specific frequency value derived from the active site of the protein is selected from a total amino acid frequency spectrum obtained by crossing these spectra, an approximate value of the specific frequency is retrieved, and consequently, a biological/functional activity of the optional protein is predicted.
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