| 摘要 |
A novel, facile, and specific process for .alpha.-iodinating or .alpha. - brominating the .alpha.-methylenic carbon of an azasteroid, comprises reacti ng the amide with trialkylsilyl-X (R3Si-X), where X is Br, I, or Cl, and R is methy l, ethyl, or n-propyl, in the presence of I2 or Br2. The .alpha.-iodo- or .alph a.- bromo-amide is useful for making the .alpha.,.beta.-unsaturated amide through dehydrohalogenation.
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