| 摘要 |
A pharmaceutical composition that inhibits or slows the growth of viruses in animals, particularly in mammals, while reducing cytoxicity of ribavirin or interferon is disclosed. This same composition can be used to treat viral infections, particularly hepatitis C. The composition preferably comprises from about 10 mg to about 6000 mg of a (5-aryl-1,2,4-thiadiazol)-3-yl thiourea derivative or (5-aryl-1,2,4-thiadiazol)-3-yl urea derivative of the formula:wherein X is oxygen or sulfur, R is hydrogen or alkyl having from 1-3 carbons, n is 0-4, R1 is independently selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, alkoxy having the formula -O(CH2)yCH3, wherein y is from 1 to 6, or a pharmaceutically acceptable acid addition salt or prodrug thereof and a safe and effective amount of ribavirin, interferon or mixtures thereof. The preferred compound is (5-phenyl-1,2,4-thiadazol-3-yl) thiourea.
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