发明名称 |
Process for preparing a 2-(2-amino-1, 6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
摘要 |
wherein Z1 is hydrogen or an amino-protecting group selected from the group consisting of acyl of the formula R-C(O)-, wherein R is alkyl of 1-6 carbon atoms; trityl, optionally substituted with methoxy; and N-(9-fluorenylmethoxycarbonyl); Y1 is halo, aralkyloxy or acyloxy, wherein acyl is as defined above; and Y2 is aralkyloxy. These intermediates are useful in a novel process for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol (ganciclovir). The mono-L-valine ester of ganciclovir and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.
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申请公布号 |
US6340756(B1) |
申请公布日期 |
2002.01.22 |
申请号 |
US20000497319 |
申请日期 |
2000.02.03 |
申请人 |
SYNTEX (U.S.A.) INC. |
发明人 |
DVORAK CHARLES A.;WREN DOUGLAS L.;FISHER LAWRENCE E.;AXT STEVEN D.;HUMPHREYS ERIC R.;ARZENO HUMBERTO B.;BEARD COLIN C.;NGUYEN SAM LINH;HAN YEUN-KWEI;ROBERTS CHRISTOPHER R.;LUND JAN P.;FATHEREE PAUL R. |
分类号 |
C07D473/00;C07D473/18;(IPC1-7):C07D473/18 |
主分类号 |
C07D473/00 |
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