GENES AND THEIR GENETIC PRODUCTS PERTINENT TO MICROSATELLITE INSTABLE (MSI+) TUMOURS
摘要
The invention relates to genes comprising coding mononucleotide microsatellites (cMNR) or dinucleotide microsatellites (cDNR). The genes can be isolated from MSI+ tumour cells. Said genes differ from corresponding genes from non-MSI+ (tumour) cells by mutations in the cMNR or cDNR and code for gene products including neopeptides. The invention also relates to the use of the genes and their gene products for the prevention, diagnosis and/or therapy of MSI+ tumours.
申请公布号
WO0204664(A2)
申请公布日期
2002.01.17
申请号
WO2001DE02510
申请日期
2001.07.04
申请人
KNEBEL DOEBERITZ, VON, MAGNUS;BORK, PEER;YUAN, YAN, PING;GEBERT, JOHANNES;WOERNER, STEFAN;LINNEBACHER, MICHAEL
发明人
KNEBEL DOEBERITZ, VON, MAGNUS;BORK, PEER;YUAN, YAN, PING;GEBERT, JOHANNES;WOERNER, STEFAN;LINNEBACHER, MICHAEL