CHEMOKINE RECEPTOR MODULATORS, PRODUCTION AND USE

摘要

Chemokine receptor modulators comprising a chemically modified carboxyl- terminus (C-terminus) and/or amino-terminus (N-terminus) for modulating potency and pharmacokinetic properties, and methods of production and use ar e disclosed. The compounds and methods of the invention are exemplified by nov el N-terminal, C-terminal and N/C-terminal analogs of CC and CXC chemokines. Th e chemokine receptor modulator analogs of the invention are useful for the treatment of disorders involving the naturally occurring chemokine that the analogs of the invention antagonize, such as for the treatment of HIV and AI DS related disorders and for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, organ transplant rejection, and rheumatoid arthritis.