COMBINATIONS OF STATINS, ESTROGENIC AGENTS AND OPTIONALLY ESTROGENS

摘要

This invention comprises methods of treating cardiovascular disorders and lowering blood LDL levels comprising administration of a statin, an estrogen and compound of the formulae (I or II): wherein Z is a moiety selected from the group of: (III) wherein: R>1< is selected from H, OH or the C>1<-C>12< esters or C>1<-C>12< alkyl ethers thereof, benzyloxy, or halogen; or C>1<-C>4< halogenated ethers including trifluoromethyl ether and trichloromethyl ether; R>2<, R>3<, R>4<, R>5<, and R>6< are H, OH or C>1<-C>12< esters or C>1<-C>12< alkyl ethers thereof, halogens, or C>1<-C>4< halogenated ethers, cyano, C>1<-C>6< alkyl, or trifluoromethyl, with the proviso that, when R>1< is H>1<, R>2< is not OH; Y is the moiety: (IV) R>7< and R>8< are alkyl or concatenated together to form an optionally substituted, nitrogen-containing ring; or a pharmaceutically acceptable salt thereof.