发明名称 |
METHOD FOR THE PRODUCTION OF HYDROXYLATED COLLAGEN-LIKE COMPOUNDS |
摘要 |
The present invention relates to a method for the production of collagen-lik e compounds containing hydroxylated proline residues. Of specific interest is the production of recombinant collagen-like compounds in which hydroxylation of proline residues is achieved by a prolyl hydroxylase from a fungus, preferably a yeast, in particular Hansenula polymorpha. Also the invention concerns a method for controlling the hydroxylation of proline residues by such a prolyl hydroxylase characterised by the addition of collagen-like oligopeptides, such as gelatine hydrolysate, in particular gelatone or pepto ne. |
申请公布号 |
CA2415464(A1) |
申请公布日期 |
2002.01.17 |
申请号 |
CA20012415464 |
申请日期 |
2001.07.11 |
申请人 |
ATO B.V. |
发明人 |
DE WOLF, FREDERIK ANTON;WERTEN, MARC WILLEM THEODOOR;DE BRUIN, ERIC CHRISTIAAN |
分类号 |
C12N9/14;C07K14/39;C12N9/02;C12P21/02 |
主分类号 |
C12N9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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