发明名称 |
BIFUNCTIONAL MOLECULES AND VECTORS COMPLEXED THEREWITH FOR TARGETED GENE DELIVERY |
摘要 |
Methods and products for targeting delivery vectors, such as adenoviral gene delivery particles, to selected cell types are provided. The methods rely on targeting by a bifunctional molecule that specifically complexes with a protein on the vector particle surface and with targeted cell surface proteins. The targeted cell surface proteins are any that activate the phosphatidylinositol-3-OH kinases. The bifunctional molecules, compositions, kits, and methods of preparation and use of the vector/bifunctional molecules for gene therapy are provided. |
申请公布号 |
WO0204522(A2) |
申请公布日期 |
2002.01.17 |
申请号 |
WO2001EP07878 |
申请日期 |
2001.07.09 |
申请人 |
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.;THE SCRIPPS RESEARCH INSTITUTE;NEMEROW, GLEN, R.;LI, ERGUANG |
发明人 |
NEMEROW, GLEN, R.;LI, ERGUANG |
分类号 |
C12N15/09;A61K35/76;A61K39/395;A61K48/00;A61P43/00;C07K14/475;C07K14/485;C07K14/525;C07K14/65;C07K16/08;C07K16/18;C07K19/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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