METHOD FOR THE PREPARATION OF CITALOPRAM

摘要

A method for the manufacture of citalopram characterised in(i) reaction of 1-(4'-fluorophenyl)-1-(3-dimethylaminopropyl)-5-halophtalane with activated magnesium to form the Grignard reagent [3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl]dimethylamine 5-magnesium halide followed by (ii) reaction of [3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl]dimethylamine 5-magnesium halide with a compound containing a -CN group bound to a leaving group to form citalopram.