发明名称 |
Promoters of neural regeneration |
摘要 |
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.
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申请公布号 |
US2002006916(A1) |
申请公布日期 |
2002.01.17 |
申请号 |
US20010900268 |
申请日期 |
2001.07.06 |
申请人 |
SONG HONG-JUN;POO MU-MING;MING GUO-LI;TESSIER-LAVIGNE MARC;HE ZHIGANG |
发明人 |
SONG HONG-JUN;POO MU-MING;MING GUO-LI;TESSIER-LAVIGNE MARC;HE ZHIGANG |
分类号 |
A61K45/00;A61K31/198;A61K31/215;A61K31/409;A61K31/445;A61K31/522;A61K31/5375;A61K31/70;A61K31/7076;A61K31/708;A61P43/00;(IPC1-7):A61K31/710;A61K31/537;A61K31/555;A61K31/401;A61K31/21 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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地址 |
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