| 摘要 |
7,8 and 9-substituted tetracyline compounds of the formula (I) wherein: R<4> and R<4'> are each methyl; R<5> is hydrogen or hydroxyl; R<6> and R<6'> are each independently hydrogen, methyl, or hydroxyl; R<7> is hydrogen, lower alkenyl, lower alkynyl, phenyl, halophenyl, acyl, phenylalkynyl, heteroaryl, or dimethylamino; and R<8> is hydrogen, phenyl, nitrophenyl, halo, or lower alkynyl; and R<9> is hydrogen, amino, acetamide, or lower alkynyl; and provided that at least one of R<7>, R<8>, or R<9> is not hydrogen, methods of treating tretracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described. |
