| 摘要 |
This invention provides methods of increasing or maintaining mammalian nitric oxide synthase activity and output of nitric oxide comprising administering a compound of the formulae: (I) wherein Z is a moiety selected from the group of (II) wherein R1 is selected from H, OH or the C1-C12 esters of C1-C12 alkyl ethers thereof, or halogens; or C1-C4 halogenated ethers including trifluoromethyl ether and trichloromethyl ether; R2, R3, R4, R5, and R6 are H, OH or C1-C12 alkyl ethers thereof, halogens, or C1-C4 halogenated ethers, cyano, C1-C5 alkyl, or trifluoromethyl, with the proviso that, when R1 is H, R2 is not OH; Y is the moiety: (III) R7 and R8 are alkyl or concatenated together to form an optionally substituted, nitrogen-containing ring; or a pharmaceutically acceptable salt thereof. |
