| 发明名称 |
PROTEIN DESIGN AUTOMATION FOR DESIGNING PROTEIN LIBRARIES WITH ALTERED IMMUNOGENICITY |
| 摘要 |
The present invention relates to the use of a variety of computational methods for modulating the immunogenicity of proteins by identifying and then altering potential amino acid sequences that elicit an immune response in a host organism. In particular, protein will be screened for MHC binding sequences, T cell epitopes and B cell epitopes. |
| 申请公布号 |
WO0205146(A2) |
申请公布日期 |
2002.01.17 |
| 申请号 |
WO2001US21823 |
申请日期 |
2001.07.10 |
| 申请人 |
XENCOR, INC. |
发明人 |
CHIRINO, ARTHUR, J.;DAHIYAT, BASSIL, I. |
| 分类号 |
G01N33/68;A61K39/00;C07K1/00;C07K1/04;C07K14/47;G01N33/48;G06F17/30;G06F17/50;G06F19/16 |
主分类号 |
G01N33/68 |
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