PIPERIDINE COUMPOUNDS FOR USE AS CCR-3 INHIBITORS

摘要

Compounds of formula (I) in free or salt form, where Ar<1> is phenyl substituted by one or more halogen atoms, Ar2 is phenyl or naphthyl which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy or C1-C8-alkoxycarbonyl, R<1> is hydrogen or C1-C8-alkyl optionally substituted by hydroxy, C1-C8-alkoxy, acyloxy, N(R<2>)R<3>, halogen, carboxy, C1-C8-alkoxycarbonyl, -CON(R<4>)R<5> or by a monovalent cyclic organic group, R<2> and R<3> are each independently hydrogen or C1-C8-alkyl, or R<2> is hydrogen and R<3> is acyl or -SO2R<6>, or R<2> and R<3> together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R<4> and R<5> are each independently hydrogen or C1-C8-alkyl, or R<4> and R<5> together with the nitrogen atom to which they are attached denote a 5- 6-membered heterocyclic group, R<6> is C1-C8-alkyl, C1-C8-haloalkyl, or phenyl optionally substituted by C1-C8-alkyl, and n is 1, 2, 3, or 4, with the proviso that when Ar<1> is p-chlorophenyl and R<1> is hydrogen, Ar<2> is not phenyl or p-nitrophenyl. The compounds are useful as pharmaceuticals.