| 摘要 |
Compositions for the diagnosis and therapy of bladder, lung, ovary, and kidn ey cancer, derived from or based on a normally prostate-specific, androgen- regulated, cell membrane associated an secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire codi ng sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) i s provided (Figure 1). Among the compositions provided are antibodies that bin d to 20P1F12/MPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods o f examining a biological sample for evidence of disregulated cellular growth b y comparing the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sampl e are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating bladde r, lung, ovary, and kidney cancer, including particularly, 20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecu le therapy.
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