The present invention generally provides taxane prodrugs comprising at least one taxane joined by hydrolyzable bond(s) to one or more polyethylene glycol oligomer(s) selected from the group consisting of a straight or branched polyethylene glycol oligomer having from 1 to 25 polyethylene glycol units and optionally comprising a salt-forming moiety. The polyethylene glycol oligomer preferably comprises a salt-forming moiety, which is preferably selected from the group consisting of ammonium and carboxylate.
申请公布号
WO0119407(A3)
申请公布日期
2002.01.17
申请号
WO2000US24523
申请日期
2000.09.07
申请人
NOBEX CORPORATION;EKWURIBE, NNOCHIRI, N.;BARTLEY, GARY, S.;PRICE, CHRISTOPHER, H.
发明人
EKWURIBE, NNOCHIRI, N.;BARTLEY, GARY, S.;PRICE, CHRISTOPHER, H.
