| 摘要 |
<p>The invention provides methods for the identification of genes and their encoded proteins involved in the susceptibility to proliferative disorders, including cancer, using a tumor host range mutant virus (T-HR mutant). In addition, the invention provides methods for the diagnosis of abnormally proliferating cells in a subject, using a T-HR mutant. The invention also features, T-HR mutants that can be used to kill cancer cells such as ones carrying a Sal2 alteration. Furthermore, the invention features the analysis of Sal2 nucleic acids and proteins for diagnosing and treating patients having proliferative disorders, including cancer, involving mutations in a Sal2 gene and encoded protein. Also encompassed by the invention are transgenic and knockout mice including Sal2 nucleic acids or proteins and mutants thereof.</p> |
