发明名称 |
NOVEL C-4 SUBSTITUTED RETINOIDS |
摘要 |
Novel C-4 substituted all-trans retinoic acid analogs are synthesized and used to treat various cancers and dermatological diseases and conditions. These novel C-4 substituted all-trans retinoic acid analogs inhibit all-trans retinoic acid (ATRA) 4-hydroxylase activity, thereby inhibiting the catabolism of ATRA. These novel C-4 substituted ATRA analogs also have ATRA-mimetic activity. The substitutions at C-4 comprise azole, sulfur, oxygen, nitrogen, pyridyl, acetylinic, cyclopropyl-amine, ester, oxime, cyano, oxirone and aziridine groups. |
申请公布号 |
WO0203912(A2) |
申请公布日期 |
2002.01.17 |
申请号 |
WO2001US16524 |
申请日期 |
2001.07.11 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;NJAR, VINCENT, C., O.;BRODIE, ANGELA, M., H.;NNANE, IVO, P. |
发明人 |
NJAR, VINCENT, C., O.;BRODIE, ANGELA, M., H.;NNANE, IVO, P. |
分类号 |
A61K31/203;A61K31/4162;A61K31/4172;A61K31/4196;A61P13/08;A61P17/00;A61P17/02;A61P17/06;A61P35/00;A61P35/02;C07C59/147;C07C69/74;C07C323/61;C07C403/20;C07D213/55;C07D233/54;C07D233/60;C07D249/08;C07D303/38;C07D331/02;C07D521/00 |
主分类号 |
A61K31/203 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|