发明名称 |
TUMOR NECROSIS FACTOR-GAMMA |
摘要 |
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
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申请公布号 |
WO0204643(A1) |
申请公布日期 |
2002.01.17 |
申请号 |
WO2001US21282 |
申请日期 |
2001.07.06 |
申请人 |
HUMAN GENOME SCIENCES, INC.;YU, GUO-LIANG;NI, JIAN;ROSEN, CRAIG, A.;ZHANG, JUN |
发明人 |
YU, GUO-LIANG;NI, JIAN;ROSEN, CRAIG, A.;ZHANG, JUN |
分类号 |
A61K38/00;C07K14/525;C07K14/705;C07K16/24;C12N15/28;(IPC1-7):C12N15/28;C07K14/00;C07K16/00;C07K16/28;C07K17/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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