| 摘要 |
<p>7,8 and 9-substituted tetracyline compounds of the formula (I) wherein: R?4 and R4'¿ are each methyl; R5 is hydrogen or hydroxyl; R?6 and R6'¿ are each independently hydrogen, methyl, or hydroxyl; R7 is hydrogen, lower alkenyl, lower alkynyl, phenyl, halophenyl, acyl, phenylalkynyl, heteroaryl, or dimethylamino; and R8 is hydrogen, phenyl, nitrophenyl, halo, or lower alkynyl; and R9 is hydrogen, amino, acetamide, or lower alkynyl; and provided that at least one of R?7, R8, or R9¿ is not hydrogen, methods of treating tretracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.</p> |
