发明名称 |
MUTATIONS OF CRYPTIC SPLICE SITES IN CRE AND CRE FUSED PROTEINS FOR IMPROVEMENT OF EXPRESSION AND INDUCIBILITY |
摘要 |
The invention relates to a DNA sequence, which codes for a mutant of the bacteriophage P1 recombinase, in which a particular cryptic splicing site is disabled by means of a base mutation which alters the Cre protein sequence. The invention further relates to a DNA sequence which codes for a fusion protein from the named Cre mutants and a ligand-binding domain of a receptor protein. The invention furthermore relates to vectors, micro-organisms and transgenic organisms, containing such a DNA sequence and Cre mutants or Cre fusion proteins which are coded by said DNA sequence.
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申请公布号 |
CA2415350(A1) |
申请公布日期 |
2002.01.17 |
申请号 |
CA20012415350 |
申请日期 |
2001.07.06 |
申请人 |
ARTEMIS PHARMACEUTICALS GMBH |
发明人 |
RAJEWSKY, KLAUS;EDENHOFER, FRANK OLIVER STEFAN;WUNDERLICH, THOMAS |
分类号 |
A01H5/00;A01K67/027;C07K14/72;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N9/10;C12N15/09;C12N15/12;C12N15/52;C12N15/62;C12N15/63;C12N15/67;C12N15/85;(IPC1-7):C12N15/12 |
主分类号 |
A01H5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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