Thiazolobenzoheterocycles, process of their preparation and preparations containing them

摘要

Thiazolobenzoheterocykly obecn ho vzorce I, kde R.sub.1.n. je s ra; R.sub.2.n. je vod k nebo alkyl; -R.sub.3.n.-R.sub.4.n.-R.sub.5.n.-R.sub.6.n.- je °et zec vzorce -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-CO-, -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-CH(R.sub.8.n.)-, -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-S-, -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-SO-, -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-SO.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-O-, -CH.sub.2.n.-CH.sub.2.n.-CH.sub.2.n.-N(R.sub.9.n.)-, -CH.sub.2.n.-CH.sub.2.n.-CO-CH.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-CH(R.sub.8.n.)-CH.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-S-CH.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-SO-CH.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-SO.sub.2.n.-CH.sub.2.n.-, -CH.sub.2.n.-C(alk) (alk')-S-CH.sub.2.n.-, -CH.sub.2.n.-C(alk) (alk')-SO-CH.sub.2.n.-, -CH.sub.2.n.-C(alk) (alk')-SO.sub.2.n.-CH.sub.2.n.-, -CH.sub.2.n.-CH(R.sub.10.n.)-S-CH.sub.2.n.-, -CH.sub.2.n.-CH-(R.sub.10.n.)-SO-CH.sub.2.n.-, -CH.sub.2.n.-CH-(R.sub.10.n.)-SO.sub.2.n.-CH.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-O-CH.sub.2.n.-, -CH.sub.2.n.-CH.sub.2.n.-N-(R.sub.9.n.)-CH.sub.2.n.- nebo -CH.sub.2.n.-CO-N-(R.sub.9.n.)-CH.sub.2.n.-; R.sub.7.n. je polyfluoralkyl nebo polyfluoralkoxyl; R.sub.8.n. je hydroxyl; R.sub.9.n. je vod k nebo alkyl nebo benzyl; R.sub.10.n. je alkyl, -CH.sub.2.n.OH, -COOalk, -COOH nebo -CONH.sub.2.n., jejich izomery, racemick slou eniny, enantiomery, jejich soli, zp soby jejich p° pravy a l iva, kter je obsahuj . Slou eniny p sob proti k°e m a zasahuj do glutamatergn ho p°enosu..sub. .n./