| 摘要 |
Methods for the separation of enantiomers of mianserin or mianserin-like compounds by using (+)- or (-)-di-p-toluoyl-(L) or (D)-tartaric acid. Also claimed are optically pure (+)- or (-)- mianserin-like compounds and pharmaceutical preparations containing these compounds. Additionally methods for treating disturbances of 5-hydroxytrytamine metabolism and histamine metabolism, and treating conditions such as depression, hypertension, congestive heart failure, migraine, anxiety, schizophrenia, gastrointestinal disturbances, diarrhoea, asthma or allergic conditions is also claimed. The mianserin-like compound has formula (1) wherein X = CH2, O, S or NR<4>, and Y = H, CN or (2); Z = O, S or NR<2>. |
