| 摘要 |
PROBLEM TO BE SOLVED: To provide a method of preparing a carbapenem compound exhibiting a strong antibacterial activity. SOLUTION: This method prepares (1R,5S,6S)-2-[1-(1,3-thiazoline-2-yl) azethidine-3-yl]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapene-2-m-3-c arboxylic acid expressed by formula (IV) by reacting 3-mercapt-1-(1,3-thiazoline-2-yl) azethidine to p-nitrobenzyl (1R,5R,6S)-2-(diphenyl-phospholyoxy)-6-[(R)-1- hydroxyethyl]-1-methyl-carbapene-2-m-3-carboxylate and then releasing p- nitrobenzyl group.
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